G. Saravanan*, V. Alagarsamy, P. Dinesh Kumar, T. Panneer Selvam and C.R. Prakash


Convulsion or epilepsy is the most common serious disorder of the brain and is characterized by recurrent unprovoked seizures. It is estimated that there are 50 million people with convulsion worldwide and the majority of cases are in the developing countries. This means almost 1 in 100 people has the condition. Convulsion usually begins during childhood, although it can start at any age. In general, heterocyclic systems consisting mainly nitrogen, oxygen, and sulfur atom form a huge class of compounds of biological and medicinal interest. A vast number of heterocyclic systems which consists mainly five and six membered analogues represent a varied group of molecular scaffolds. A number of such heterocyclic scaffolds have been effectively incorporated into new drug leads and therapeutic agents. On the other hand, Schiff and Mannich bases, the condensation products of aromatic aldehydes with aromatic amines, have been recognized to have a wide variety of biological applications. Furthermore, Schiff and Mannich bases derived from different heterocyclic scaffolds especially isatin covers a wide range of pharmacological potential which includes mainly anticonvulsant activity. In addition literature review also indicates that Schiff and Mannich base of isatin derivatives showed outstanding anticonvulsant activity. The present review summarizes anticonvulsant activities of isatin analogs.

Keywords: Isatin, Indole-2,3-dione, Anticonvulsant, Neurotoxicity, MES.

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