Abstract
EFFECT OF FRUIT OF CUMINUM CYMINUM ON ETHYLENE GLYCOL (EG) INDUCED UROLITHIASIS IN RATS.

Venu A.*, G. Sandhyarani and Purnachander M.

ABSTRACT

To evaluate the antiurolithiatic effect of the methanolic extracts of the fruit of c. cyminum on ethylene glycol (EG) induced urolithiasis in rats. To evaluate urinary excretion of calcium and phosphorous in normal and induced groups. To evaluate urinary excretion of calcium and phosphorous in methanolic extract treated groups. Collection and Authentication of plant. Preparation of extract of seeds using 95%v/v methanol as a solvent. Albino rats (wistar strain), weighing 150-200g, were procured from the Teena biolabs pvt. Ltd. (Reg, no. 177/99 CPCSEA). Rangareddy, Andhrapradesh. The animals were kept in polypropylene cages (6 in each cage) and free access to commercial pellet diet with water ad libitum. Methanolic extract of c. cyminum Linn, significantly reduced the elevated levels of calcium, phosphorous, blood urea nitrogen, uric acid & serum creatinine in curative & preventive treatment groups. The histopathological findings also show sign of improvement after treatment with the methanolic extract of c. cyminum. All these observation provided that the basis for the conclusion that c. cyminum Linn seed extract inhibited the stone formation induced by ethylene glycol treatment.

Keywords: Antiurolithiatic, methanolic, c. cyminum.


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