Abstract
“STUDY OF ASSOCIATION OF OXIDATIVE STRESS AND INFLAMMATION IN NEUROPSYCHIATRIC DISORDERS”

Dr. Santoshi R. Ghodake* and Dr. Adinath N. Suryakar

ABSTRACT

Objective: Neuropsychiatric disorders represent the second largest cause of morbidity worldwide having very complex etiopathophysiology. Several lines of evidence suggesting that inflammatory reactions are most common features of all forms of neuronal disorders. There is growing evidences also suggests increased oxidative stress and inflammation in patients with schizophrenia. To assess the lipid peroxidation, Malondialdehyde (MDA), Total antioxidant capacity (TAC) uric acid were estimated. To estimate the activity of Adenosine deaminase (ADA) as inflammatory marker in neuropsychiatric disorders. Also study was aimed to assess the impact of antioxidant supplementation on these parameters in patients with neuropsychiatric disorders. Method: The study group included a total of 90 subjects of which 30 were schizophrenic patients, 30 were major depressive patients and 30 were healthy controls. Statistical analysis was performed using student 't'test. Results: Serum MDA (Group I, p<0.0001 Group II, p<0.05) and ADA (Group I, p< 0.0001, Group II, p<0.05) levels were found to be significantly high in both group patients (schizophrenics and depression) when compared to controls. Significant decreased levels of TAC (Group I and II, p<0.0001) and uric acid (Group I and II, p<0.05) level in were observed in both groups. After antioxidants supplementation significant changes were found in the levels of MDA, TAC, uric acid and ADA activity. Conclusion: We conclude that increased serum ADA activity indicates inflammation and increased MDA level indicates oxidative stress in neuropsychiatric disorders, schizophrenia and depression. The data showed that decrease in plasma TAC and uric acid, suggesting increased oxidative stress. Inflammatory biomarkers are known to play an important role in initiation and progression of disease along with oxidative damage.

Keywords: Adenosine deaminase, Malondialdehyde, Oxidative stress, Inflammation, Neuropsychiatric disorders.


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