Abstract
STUDIES ON DEVELOPMENT AND CHARACTERIZATION OF GLIMEPIRIDE MICROSPHERES

Sai Charitha CH* and Rama Rao Nadendla

ABSTRACT

The present study is to develop glimepiride microspheres, an orally administered anti-diabetic drug with an idea of improving its oral bioavailability and giving a prolonged drug release. Glimepiride microspheres were successfully formulated by emulsification solvent evaporation technique using polymers such as ethyl cellulose and combination of HPMC and ethyl cellulose. The percentage yield obtained in all the formulations was good. The particle size of microspheres was increased with increase in the concentration of polymer. Scanning electron microscopy showed that microspheres of drug with combination of HPMC and ethyl cellulose showed smooth surface and a good spherical shape. The in-vitro drug release studies showed that drug release was more in case of formulations F7 containing both hydrophilic and hydrophobic polymers in the ratio 1:1 as compared to other formulations.

Keywords: Glimepiride, HPMC, Ethyl cellulose, Oral bioavailability.


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