Abstract
STUDIES ON DEVELOPMENT AND CHARACTERIZATION OF GLIMEPIRIDE MICROSPHERES

Sai Charitha CH* and Rama Rao Nadendla

ABSTRACT

The present study is to develop glimepiride microspheres, an orally administered anti-diabetic drug with an idea of improving its oral bioavailability and giving a prolonged drug release. Glimepiride microspheres were successfully formulated by emulsification solvent evaporation technique using polymers such as ethyl cellulose and combination of HPMC and ethyl cellulose. The percentage yield obtained in all the formulations was good. The particle size of microspheres was increased with increase in the concentration of polymer. Scanning electron microscopy showed that microspheres of drug with combination of HPMC and ethyl cellulose showed smooth surface and a good spherical shape. The in-vitro drug release studies showed that drug release was more in case of formulations F7 containing both hydrophilic and hydrophobic polymers in the ratio 1:1 as compared to other formulations.

Keywords: Glimepiride, HPMC, Ethyl cellulose, Oral bioavailability.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2024 Issue has been successfully launched on 1 MAY 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT