Bhargavi Yanamadala*, Sushma Attuluri, Dr. Aishwarya Dinakaran, Dr. Aliya Parveen, Tahmina Sultana, Sahithi K.


Background and Objective: Carica papaya leaves exhibits wide range of biological functions such as antifungal, antimalarial, anti-inflammatory, anticancer, antisickling etc and purple grapes demonstrates anticancer, antihyperglycemic and wound healing activities. The present study was focussed on potential benefits of carica papaya leaves and purple grape juice on thrombocytopenia. The study also investigates the combined effect of carica papaya leaves and purple grape juice and its formulation in treating thrombocytopenia. Methods: The Sprague dawley rats of either sex weighing between 150-200 Gms were used. Animals received the test compound or the vehicle (controls) by oral route for 10 days. After 10 days, blood samples were collected from the treated rats under ether anaesthesia and platelets were counted using haemocytometer. Heparin was administered subcutaneously and blood samples were collected at 60 min and 24 hrs after the administration of heparin to estimate the platelet count. The percentage change in the thrombocytes count was determined in all groups. Body weight was checked every 5 days and was tabulated. Results: Homogenate of carica papaya leaves and purple grapes were found to be effective in increasing platelet count at both the doses (200 mg/kg and 500 mg/kg p.o.). Moreover, combination of papaya leaves (200 mg/kg) and purple grape (500 mg/kg) was significantly more effective in terms of increasing platelet count when compared to normal control. Similarly, formulation continue to preserve the efficacy of the therapeutic benefits of combination of papaya leaves and purple grape in ratio of 1:2.5 for ameliorating thrombocytopenia as well as maintaining body weight. Interpretation and Conclusion: Homogenate of carica papaya leaves and purple grapes were found to be effective in elevating platelet count at both low (200 mg/kg) and high doses (500 mg/kg) when given orally. Combination of the carica papaya leaves low dose and purple grapes high dose attenuated the progression of thrombocytopenia by increasing platelets count. Formulation of combination of papaya leaves and purple grapes was found equally effective as combination. Hence formulation of combination may be potentially useful in treating thrombocytopenia.

Keywords: Thrombocytopenia, Platelets, Carica papaya leaves, Purple grapes, Heparin.

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