Abstract
DESIGN AND EVALUATION OF METFORMIN ORAL MUCOADHESIVE TABLETS: EFFECT OF POLYMERS ON EVALUATION PARAMETERS

M. Ravindra Babu*, M. Lakshmi Pravallika and Rekha Rani

ABSTRACT

An attempt has been made to develop oral mucoadhesive tablets for a drug like metformin which shows antidiabetic action. Hydrophilic polymers like high viscous sodium alginate and low viscous sodium alginate were used in the preparation. By using these polymers six formulations of oral mucoadhesive tablets were formulated by wet granulation method. The prepared tablets were subjected for evaluation of hardness, weight variation, thickness, friability, swelling behavior, mucoadhesion strength, invitro release rate study. Formulation F2 containing more amount of high viscous sodium alginate is found to be optimized formulation. The invitro release of F2 formulation exhibits sustained release of metformin.

Keywords: Metformin, Sodium alginate, Mucoadhesion, oral mucosa.


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