Abstract
EFFECT OF MLEAA TREATMENT ON THE LIPID PROFILE OF THE DIABETIC RAT BRAIN IN COMPARISON WITH METFORMIN DRUG

Busineni Jayasimha Goud* and B. K. Chikka Swamy

ABSTRACT

The present investigation was intended to probe the response of MLEAA (methanolic leaf extract of Artemisia absinthium) treatment on the levels of lipid profile in experimental diabetic rats. A total of 40 male rats were divided into 5 groups, 8 in each group; Normal group (N), the Normal group treated with Artemisia absinthium (NA), Diabetic group (D), Diabetic group treated with Artemisia absinthium (DA) and Diabetic group treated with metformin (DM). STZ (Streptozotocin-55 mg/kg body weight) was used to induce diabetes mellitus through intraperitoneal injection in normal male Wistar rats by a lone shot. Two months treatment with MLEAA has produced a notable rise in the content of total lipids (TL), phospholipids (PL), glycolipids (GL) and cholesterol (C) in the diabetic group rats, but a momentary decrease in triglyceride content in DA group rats was reported when compared to D group rats like in DM group rats that has been medicated with metformin drug. DA group rats that were treated with MLEAA for 2 months has emphasized the defensive response of the Artemisia absinthium plant against STZ induced diabetes in Wistar albino rats in comparison to metformin, a commercial antidiabetic drug.

Keywords: Total lipids (TL), phospholipids (PL), glycolipids (GL) and Metformin.


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