Abstract
FORMULATION & EVALUATION OF ETHYL CELLULOSE MICROSPHERES CONTAINING GLIPIZIDE BY EMULSIFICATION METHOD

*Maya Sharma, P.K. Choudhury, Kajal L. Jain, Suresh Kumar Dev and Rajnish Shrivastava

ABSTRACT

The aim of the study was to formulate and evaluate microspheres sustained release preparations of glipizide using ethyl cellulose as the entrapment material with high entrapment effectiveness and extended release. Microspheres were prepared by the double emulsion solvent diffusion method. Microspheres prepared by acetone as solvent and light liquid paraffin was chosen as the primary oil phase. Span-80 was used as the surfactant for stabilizing the liquid paraffin as oil phase. The prepared microspheres were characterized by percentage yield, shape, drug entrapment, optical microscopy and scanning electron microscopy (SEM). The in vitro release studies were performed in a series of buffer solutions with variable pH (1.2-7.4). The drug loaded microspheres showed 55–85% of entrapment and the release were extended for up to 10 hrs. SEM studies exposed that the microspheres were spherical and porous in nature. Data obtained from in vitro release studies were fitted to various kinetic models and high correlation was obtained with the Zero order kinetic. The drug release was found to be diffusion controlled.

Keywords: Microspheres, Sustained release, Glipizide, Floating microspheres.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2024 Issue has been successfully launched on 1 MAY 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT