“SOLID AS SOLVENT”- NOVEL SPECTROPHOTOMETRIC ANALYTICAL METHOD FOR QUANTITATIVE ESTIMATION OF GATIFLOXACIN TABLETS USING SOLIDS (EUTECTIC LIQUID OF PHENOL AND LIGNOCAINE HYDROCHLORIDE AS SOLUBILIZING AGENTS (MIXED SOLVENCY CONCEPT)
Rajesh Kumar Maheshwari, Nupur Maheshwari, Neelesh Maheshwari, Tilotma Sahu* and Jitendra Jain
ABSTRACT
Solubility enhancement of various poorly soluble compounds is a challenging task for researchers and pharmaceutical scientists in today’s scenario. Solubility is one of the important parameter to achieve preferred concentration of drug in systemic circulation to obtain desired pharmacological response. The present investigation is an attempt to show that solids can also be wisely used to act as solvent precluding the use of organic solvents. The main objective of the present study is to demonstrate the solvent action of solid. Solid excipients can nicely be employed as solubilizers in the development of pharmaceutical dosage forms in solution form of poorly soluble drugs (mixed solvency concept). Present study describes the application of solvent character of eutectic liquid consisting of phenol and lignocaine hydrochloride in 4:1 ratio (PL-41) on the weight basis for spectrophotometric estimation of gatifloxacin tablets. Solubility of gatifloxacin in distilled water was found to be 1.31 mg/ml at room temperature. More than 120 mg of gatifloxacin dissolves in 1 ml of PL-41. In the present investigation, PL-41 was utilized to extract out (dissolve) the drug from tablet powder of gatifloxacin tablets. Distilled water was used for dilution purpose. Absorbance was noted at 333 nm against reagent blank to calculate the amount of drug in the tablets. Proposed method is novel, eco-friendly, rapid, free from toxicity of organic solvent, accurate and reproducible. Recovery studies and statistical data proved the accuracy, reproducibility and precision of the proposed method. The presence of phenol, lignocaine hydrochloride and tablet excipients did not interfere in the spectrophotometric estimation of gatifloxacin at 333 nm. Phenol and lignocaine hydrochloride do not interfere at 333 nm in spectrophotometric analysis.
Keywords: Mixed-solvency concept, gatifloxacin, phenol, lignocaine hydrochloride, eutectic liquid, spectrophotometric analysis.
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