Abstract
PHYTOCHEMICAL SCREENING AND HYPOGLYCEMIC EFFECT OF SELECTED MEDICINAL PLANT

Amrin Tabassum*, Mohammed Nayeem Uddin, Tahmina Sultana, Urooj Fatima, Ayesha Sultana and Syed Ashfaq Hussain

ABSTRACT

Background and Objective: To investigate the anti diabetic activity of Glycyrrhizae Radix ethanolic extract in rats. Methodology: Rats were treated with Alloxan at a dose of 120 mg/kg I.P. for 09 days. So as to develop insulin resistance the Ethanolic extract of Glycyrrhizae Radix was administered concurrently from day 2nd P.O. twice daily. Values of fasting blood glucose and serum triglycerides were determined on 10th day. Result: There is a significant decrease P<0.001 in blood glucose level at two dose of the extract tried in the Alloxan treated model (250mg/kg) and 500mg/kg. Higher dose showed a significant decrease p<0.005 in serum triglyceride. Interpretation and Conclusion: The roots extract produces significant hypoglycemic activity in Alloxan model. Decrease in blood glucose level appears to be more due to its ability to modify the insulin action rather than to interfere with digestion and absorption of carbohydrates.

Keywords: Acetyl-Co Carboxylase, World Health Organization, Glycyrrhizae Radix, Adenosine Diphosphate, Diabetes Mellitus.


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