Abstract
ASSESSMENT OF THE EFFICACY AND TOLERABILITY OF A FIXED DOSE COMBINATION OF NEBIVOLOL AND AMLODIPINE ESSENTIAL HYPERTENSION

Anita Dharmavarapu*, Sushma Attuluri, Nuha Rasheed, Phani Kumar Nimmala, Himanshu Rai and Sahithi K.

ABSTRACT

Aim: From the literature review we found that no comparison study has been done between the combination of Nebivolol/Amlodipine with Atenolol/Amlodipine in Indian patient. So current study is being designed to compare the two combination therapy in treatment of essential hypertension. Objective: The primary objective was to demonstrate that Nebivolol–Amlodipine combination therapy is superior to Atenolol-Amlodipine combination therapy with respect to mean fall in systolic blood pressure (SBP) and diastolic blood pressure (DBP). The secondary objective was to compare the response rate and to evaluate the tolerability of study medications between 2 treatment groups. Results: Our study has shown that once daily treatment with Nebivolol /Amlodipine offers superior antihypertensive efficacy over Atenolol/Amlodipine combination therapy in patients with mild-to-moderate essential hypertension.

Keywords: Atenolol, Renin Angiotensin System, Blood Pressure, Renin-Angiotensin-Aldosterone system, efficacy.


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