Abstract
INVESTIGATION OF IN VIVO ANTIOXIDANT ACTIVITY OF METHANOL EXTRACT OF POLYGONUM GLABRUM

Raja S.* and Ramya I.

ABSTRACT

The aim of present study was to assess the in vivo antioxidant property of methanol extract of whole plant of Polygonum glabrum (polygonaceae). The rats were administered with methanol extract of Polygonum glabrum at two different doses (200mg/kg, 400mg/kg) for a period of 21 days to estimate the oxidative stress parameters including ferric reducing ability of plasma (FRAP), lipid peroxidation, reduced glutathione (GSH) and antioxidant enzymes (catalase and superoxide dismutase). FRAP analysis showed that both the doses of methanol extract possessed better reducing power in comparison to control group. The extract (400mg/kg) treatment group exhibited a significant (p<0.05) increase in serum levels of catalase and superoxide dismutase when compared with other groups. Similarly, pretreatment with methanol extract of Polygonum glabrum at the dose level of 400 mg/kg significantly restored the levels of catalase, superoxide dismutase and reduced glutathione in tissue (liver, heart and kidneys) homogenates. In addition, the tested doses of methanol extract of Polygonum glabrum (200mg/kg and 400mg/kg) possessed significant (p<0.05) antioxidant activity by effectively preventing lipid peroxidation levels in serum and tissues. Thus the overall efficacy indicates that methanol extract of Polygonum glabrum could be used as a bioactive source of natural antioxidants.

Keywords: Polygonum glabrum, Oxidative stress, Antioxidant enzymes, Catalase, Lipid peroxidation.


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