Abstract
INVESTIGATION OF FUNCTIONALITY OF NOVEL GRANULATION BINDER- DISINTEGRANT IN FORMULATION OF AMOXICILLIN TRIHYDRATE DISPERSIBLE TABLETS

Sharwaree R. Hardikar*, Ashok V. Bhosale, Mitali D. Jagtap and Pooja B. Khatate

ABSTRACT

An excipient is the component other than active ingredient; added to the formulation to perform proposed function. Binders confer structural strength required to the tablets i.e. compactibility and disintegrant is an essential component to provoke disintegration followed by dissolution of tablets. Starch is used as binder and /or disintegrant in tablet formulations but has to be added in high proportion to get its duel functionality. Novel blend of HPMC K100LV and gel obtained from psyllium husk was investigated for its dual functionality as ‘granulation binder-disintegrant’ in the present work. Granulation binder functionality of novel blend was confirmed by Heckel treatment and mechanism of disintegration was determined by adopting the strategy suggested by Bele and Derle, 2012. Novel blend disintegrated by swelling as well as deformation. Dispersible tablet formulation of amoxicillin trihydrate was developed and prepared by using a novel blend as a ‘granulation binder-disintegrant’. A 22 factorial design was implemented to study the effect of formulation and processing variables on the performance of dispersible tablet formulation of amoxicillin trihydrate. It was observed that tablets prepared at high compression pressure disintegrated faster; and hardness was also increased as novel ‘granulation binder-disintegrant’ imparted more compactibility at high pressure.

Keywords: Granulation binder-disintegrant, compactibility, psyllium husk, Heckel equation.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2024 Issue has been successfully launched on 1 MAY 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT