Abstract
PREPARATION AND IN-VITRO EVALUATION OF FLOATING CONTROLLED POROSITY OSMOTIC PUMP TABLETS OF CAPTOPRIL

C. Pradeep Kumar, B. Bhagya, Ch. Saritha, Dr. Shayeda*

ABSTRACT

Osmotically Controlled Drug Delivery Systems (OCDDS) are the Novel Drug Delivery Systems (NDDS) that can overcome the limitations of sustained and controlled drug delivery systems. Osmotic systems utilize the principles of osmotic pressure for the delivery of drugs. Oral osmotically controlled release delivery system provide a uniform concentration of drug at the absorption site and maintains plasma concentration within therapeutic range. Osmotic pumps can be used as experimental tools to determine important pharmacokinetic parameters of new or existing drugs. At the same time, they can also be utilized to deliver drugs at a controlled and predetermined rate. The aim and objectives of Present study were to design and formulate Floating Controlled Porosity Osmotic Pump Tablets for Captopril. Optimum formulation was determined by Box-Behnken Design Expert 9.0 software and the physicochemical characteristics of formulations were found to be stable. in-vitro drug release studies were performed for of all formulations and delivered Captopril for a period of 12 hrs independent of pH and agitational intensity. The system FOP3 was found to be optimum. This system is simple to prepare and is cost effective, alternative to conventional osmotic delivery pump as the sophisticated laser drilling technique is not required.

Keywords: Controlled porosity Osmotic pump, Captopril, Box-Behnken Design, in-vitro release studies.


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