IMPROVEMENT IN SOLUBILITY AND DISSOLUTION RATE OF GLIMEPIRIDE USING MELTABLE HYDROPHILIC CARRIERS
Amaresh Chandra Sahoo*, Sunil Kumar Kanungo, Subas Chandra Dinda, Jnyanaranjan Panda and Ch. Niranjan Patra
ABSTRACT
Glimepiride is a third generation of hypoglycemic drug useful in the treatment of non-insulin dependent diabetes mellitus It is a white crystalline powder, relatively insoluble in water, exhibits slow GI absorption rate and poor bioavailability. The objective of the present research is to improve the solubility and dissolution rate of glimepiride using meltable hydrophilic carriers like PEG 6000, PEG 10000 and gelucire 44/14. Phase solubility studies showed negative values for all the 3 carriers at various concentrations (0-5% w/v), indicating the spontaneous nature of solubilization. The solid dispersion exhibiting highest solubility (F8) was formulated into a rapidly dissolving minitablet using sodium starch glycolate as superdisintegrant. FT-IR and DSC studies revealed that glimepiride is compatible with carriers used in this study. The minimum quantity of neusilin US2 required for achieving the desired flowability and compressibility was 0.5 parts of carrier. Q30 values for formulation F13 showed more than 10 fold increase in dissolution rate compared to glimepiride. The rapidly dissolving minitablets of glimepiride were prepared successfully with a dissolution rate of more than 85% in 30 min.
Keywords: PEG6000, PEG10000 and gelucire 44/14.
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