European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW ARTICLE ON SUSTAINED RELEASE MATRIX TYPE DRUG DELIVERY SYSTEM

Hakadeini Challam* and Dr. Pulak Deb

ABSTRACT

The oral route is the most frequently used route for the administration of drugs. Many of the pharmaceutical dosage form are formulated as sustained release dosage form to retard the release of a therapeutic agent such that its appearance in the systemic circulation is prolonged and its plasma profile is sustained in duration. Matrix tablets serves as an important tool for oral extended- release dosage forms. Hence, problems like patient compliance, drug targeting, local side effects, frequent administration and fluctuations in blood concentration levels. Oral extended release drug delivery system becomes a very promising approach for those drugs that are given orally but having the shorter half-life and high dosing frequency. Extended-release drug-delivery system reduces the dosing frequency of certain drugs by releasing the drug slowly over an extended period of time Matrix tablets may be formulated by wet granulation or direct compression methods by dispersing solid particles within a porous matrix formed of hydrophilic and hydrophobic polymers. The use of different classes of polymers in controlling the release of drugs has become the most important aspect in the formulation of matrix tablets. The drug release in matrix drug delivery systems by both dissolution-controlled as well as diffusion controlled mechanisms.

Keywords: Direct compression, extended-release, hydrophilic and hydrophobic polymers, matrix tablets, wet granulation.