Abstract
STUDIES ON SYNTHESIS AND ANTIFUNGAL ACTIVITY OF PYRAZINE CONNECTED 1,2,4-TRIAZOL DERIVATIVES

B. Venkata Reddy*, B. Prasanna and K. Mukkanti

ABSTRACT

Encouraged by the broad spectrum of biological activities of pyrazine and 1,2,4-triazoles, we have decided to synthesis a novel series of 4-(benzylidene-amino)-5-(4-methyl-2-pyrazin-2-yl-thiazol-5-yl)-4H-[1,2,4]triazole-3- thiol and its derivatives (6a-f) by involving various intermediates like 4-methyl-2-pyrazin-2-yl-thiazole-5- carboxylic acid ethyl ester (2), 4-methyl-2-pyrazin-2-yl-thiazole-5-carboxylic acid hydrazide (3), potassium N-(4- methyl-2-pyrazine-2-yl-thiazole-5-carbonyl)-hydrazine carbodithioate (4) and 3-methyl-5-(4-methyl-2-pyrazin-2- yl-thiazol-5-yl)-[1,2,4]-triazol-4-ylamine (5) and from pyrazine-2-carbothioic amide (1) as raw material. Structures of the synthesized compounds were elucidated by IR, 1H-NMR and mass spectral data. All of the compounds were tested for antifungal activity and found that all the compounds exhibited marginal to good antifungal activity.

Keywords: Pyrazine, 1,2,4-Triazole, antifungal activity.


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