Abstract
DEVELOPMENT AND CHARACTERIZATION ORAL DISINTEGRATING TABLETS OF ANTI-PSYCHOTIC DRUG USING SPRAY DRYING TECHNOLOGY

Sunil Kumar Shah*, Gaurav K. Chaurasiya, Harish Pandey, C. K. Tyagi and Neelesh Chaubey

ABSTRACT

In this study, an attempt has been made to formulate oral disintegrating tablets, which are usefull for the patients suffering from panic disorder and cannot swallow solid oral dosage forms. The study included average weight, thickness, hardness, disintegration time, Wetting time, friability, In vitro drug release studies as post compression parameters and Stability study. All the formulation F1, F2, F3, F4, F5, F6 showed acceptable physicochemical properties like thickness, weight variation, hardness, drug content uniformity and In vitro drug release but F4 formulation showed best result in terms of disintegration time, friability, mouth feel property and wetting time due to better coating or encapsulation of superdisintegrant particle by mannitol solution in water and disintegration of tablet in particle level. So the F4 formulation was chosen as final optimized formulation. A physicochemically stable oral disintegrating formulation of drug X was successfully designed. Amongst all trials, F4 (containing 80% co-processed excipient with an ratio of polyplasdone XL10 & mannitol 25C is 1:3; inlet temperature 190-195ËšC) was found to be the most suitable oral disintegrating tablet formulation. The results indicated that formulation were stable including as supported data on content uniformity and dissolution profile so it indicated that the optimized formulation was stable.

Keywords: Orodispersible tablets, bioavailability, fast dissolving tablets, Terbutaline sulphate.


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