Abstract
FORMULATION AND EVALUATION OF GASTRORETENTIVE TABLET CONTAINING AN ANTIBIOTIC DRUG

R. A. Darakhe*, G. D. Mehetre and R. R. Thenge and N. M. Mahajan

ABSTRACT

Ciprofloxacin is a broad spectrum fluoroquinoline antibiotic effective in a broad range of infections including some difficult to treat ones. Because of wide-spectrum bactericidal activity, oral efficacy and good tolerability, it is used in Urinary tract infection, Gonorrhoea, Bacterial gastroenteritis, Typhoid, Bone, soft tissue and gynaecological infection, Respiratory infection and tuberculosis. The main objective of formulating the floating system was to reduce the frequency of administration, to improve patient compliance and improve bioavailability of drug by preparing a gastroretentive drug delivery system. Floating tablets of Ciprofloxacin were prepared by employing two different grades of control releasing polymers HPMC K4M and HPMC K100M in different concentration. Sodium bicarbonate was incorporated as a gas-generating agent. The tablets were evaluated for uniformity of weight, hardness, friability, drug content, Floating behavior, Swelling studies and dissolution studies. Among tablet formulation, formulation F3 shows maximum drug release i.e. 92.25% at the end of 12 h compared with other formulations.

Keywords: Ciprofloxacin HCl, Floating tablets, HPMC K4M, HPMC K 100M, FTIR.


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