SOLUBILITY ENHANCEMENT OF METRONIDAZOLE AND ITS TOPICLA EMULGEL FORMULATION BY USING CUBOSOMAL TECHNIQUE
B. A. Bhairav*, Amol Main and R. B. Saudager
ABSTRACT
The purpose of this research was to prepare and evaluate a cubosomes of Metronidazole, a anti-fungal by using different ratios of monoglyceride and polymer by top-down technique accompanied by homogenization. Nine formulations of Metronidazole cubosomes were prepared by using GMO as lipid emulsifier and Poloxamer 407 (P-407) as polymer in varying concentration and P-407 was also used as permeation enhancer and stabilizer. Metronidazole having a anti-fungal activity. Unfortunately these medicaments have major problem of solubility caused by systemic administration. Furthermore, poor aqueous solubility of Metronidazole limits its formulation as topical dosage form. Therefore, an improved Metronidazole formulation with high degree of permeation could be useful in Fungal infection. Transdermal delivery of Metronidazole alleviates the side effects caused by systemic administration. Transdermal delivery will also allow the drug to be delivered from cubosomes precisely into the body at the specific area of infection and at a controlled release manner due to its less viscosity.
Keywords: Poloxamer 407, top-down technique, cubosomes, and vesicular drug delivery system.
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