Abstract
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL N-ACYLHYDRAZONE DERIVATIVES

Pankaj K. Godhaviya*, Praful K. Patel and Dinesh S. Kundariya

ABSTRACT

A series of novel N-acylhydrazone derivatives was synthesized via condensation of acid hydrazide with different substituted acetophenone in the presence of catalytically acetic acid using methanol or ethanol as a solvent. The structures of synthesized compounds were confirmed by using elemental analysis, Mass, IR and 1H NMR spectroscopy. Also compounds were tested for their antibacterial and antifungal activity (MIC) in vitro with two Gram-positive bacteria, two Gram-negative bacteria and three fungal strains.

Keywords: N-acylhydrazone, acid hydrazide, acetophenone.


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