FORMULATION AND EVALUATION OF BENAZEPRIL HYDROCHLORIDE IMMEDIATE RELEASE TABLETS
Santhosh Kumar K, Rajesh Kumar Putta*, Ravi Shankar K, Reddy GNVC
ABSTRACT
The objective of this study was to formulate and evaluate fast dissolving tablets of Benazepril by direct compression technique using various polymers like microcrystalline cellulose, starch, lactose and superdisintegrant like crospovidone using direct compression technique. Benazepril is an ACE Inhibitor used in the management of
hypertension. The drug and excipients were subjected for compatability studies by FTIR. Later the formulations were evaluated for their pre compressional, post compressional parameters and In vitro drug release studies. The FTIR compatibility study revealed that there are no drug polymer interactions. The powder beds of all formulations exhibited uniform flow and ability and ease of compression. The prepared tablet showed uniformity with respect to their weight variation, thickness, friability and hardness; further the results indicated that the prepared tablets have sufficient mechanical strength and other parameters were within the specified limits. Different formulations showed disintegration time between the range of 2 min. In-vitro dissolution studies among all the formulations, formulation F6 containing (30 mg) Crospovidone showed 100% drug release within 45 min. Thus, formulation F6 was considered as optimized formulation than others. These results of the above study revealed that fast dissolving tablets of Benazepril could be formulated for immediate drug release to ensure symptomatic relief which leads to improved patient compliance.
Keywords: Immediate release tablet, Crospovidone, Benazepril, Release kinetics.
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