European Journal of Biomedical and Pharmaceutical Sciences

TOXICOLOGIAL PROFILING OF A SIDDHA FORMULATION NAAURUVI KUZHITHYLAM IN EXPERIMENTAL RODENTS

Esaivani S.*

ABSTRACT

Naauruvi Kuzhithylam (NKT) is a Siddha herbal formulation indicated in literature for Respiratory ailments. This study was aimed to evaluate the Acute and Sub acute oral toxicity study of Naauyurivi Kuzhithylam (NKT) in albino mice and Wistar rats respectively to reevaluate the traditional claims for the safety of the test drug. It was observed that the formulation was found to be non-toxic at dosage of 5000mg/kg/po in mice and so it can be classified under category-5 of globally harmonized system of classification and labelling of chemicals. The biochemical and hematological parameters were analyzed and the Histopathological study was performed for 28 days repeated oral toxicity. The data were statistically analyzed using one-way analysis of variance (ANOVA) using INSTAT-V3 software package and the results were expressed in mean ± SD. Through this study the Siddha formulation Naauruvi Kuzhithylam (NKT) can be evidently accepted to be non toxic in nature and its safety is accredited.

Keywords: Naauruvi Kuzhithylam (NKT), Siddha, Acute toxicity, Sub acute Toxicity, Traditional medicine, Herbal medicine.