ANTITUMOUR ACTIVITY OF PHYLLANTHUS NIRURI ROOT EXTRACT AGAINST 7, 12- DIMETHYLBENZ (A) ANTHRACENE INDUCED MOUSE SKIN CARCINOGENESIS
Wasim Raja*, Amit Dubey and Mahesh Gopal Patel
ABSTRACT
Chemoprevention is an important strategy to control the process of carcinogenesis. The potential of using medicinal herbs as cancer chemopreventive nutraceuticals and functional food is promising. Thus, there is a need for exploring drugs/agents which act as chemopreventive agents. Phyllanthus niruri is a well known medicinal plant which has been used in Ayurvedic medicine as hepatoprotective, antiviral, antibacterial, analgesic, antispasmodic and antidiabetic. In the present investigation, the anticancer activity of Phyllanthus niruri root extract was evaluated using two stage skin carcinogenesis in Swiss albino mice, induced by a single application of 7,12-dimethyadenz(a)anthrecene (104 μg/100 μl acetone) and one weeks later, promoted by repeated application of croton oil (1% in acetone/thrice a week) till the end of the experiment (16 weeks). The tumor incidence, tumor yield, tumor burdon and cumulative number of papillomas were found to be higher in the control (without Phyllanthus niruri treatment) as compared to experimental animal (Phyllanthus niruri treated). The difference in the values of the results of experimental group were statistically analyzed and found to be significant in comparison to the control group (p<0.05). The results thus suggest that P. niruri extract exhibits significant anti-tumor activity, which supports the traditional medicinal utilization of this plant. In conclusion, the present study demonstrates the chemopreventive of Phyllanthus niruri root extract on DMBA induced skin tumorigenesis in Swiss albino mice.
Keywords: Chemopreventive, Papilloma, Tumor, Phyllanthus niruri, Skin carcinogenesis.
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