Abstract
DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRY SIMULTANEOUS EQUATION METHOD FOR ESTIMATION OF ATENOLOL AND NIFEDIPINE IN BULK AND TABLET DOSAGE FORM

Dr. Bhavna A. Patel*

ABSTRACT

The aim of present work was to develop an accurate, simple, sensitive and Cost effective UV Spectrophotometric method for simultaneous estimation of Atenolol and Nifedipine. The method has followed linearity in the range of 5-25μg/ml and 1.25-6.25μg/ml for Atenolol and Nifedipine respectively. The value of correlation coefficient was 0.9987 & 0.9980 for Atenolol and Nifedipine at 274.5 nm and 0.9979 & 0.9970 for Atenolol and Nifedipine at 235 nm. Satisfactory values of Percent relative standard deviation for the intra-day and inter-day precision indicated that method is precise. Results of the recovery studies (97.77 % to 99.39% for Atenolol & 98.40 % to 100.37 % for Nifedipine) showed accuracy of the method. LOD calculated as 0.97μg/ml and 0.097μg/ml for Atenolol and Nifedipine at 274.5 nm & 0.46μg/ml and 0.07325μg/ml for Atenolol and Nifedipine at 235 nm. LOQ calculated as 2.94μg/ml and 0.322μg/ml for Atenolol and Nifedipine at 274.5 nm & 1.41μg/ml and 0.222μg/ml for Atenolol and Nifedipine at 235 nm .The developed method was extended to the formulation for routine estimation of Atenolol and Nifedipine.

Keywords: Atenolol, Nifedipine, UV Spectrophotometry Simultaneous Equation Method, Validation.


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