ANTIHYPERGLYCEMIC ACTIVITY OF NISHAMALAKI-AN AYURVEDIC FORMULATION OF TURMERIC AND EMBLICA OFFICINALIS
Prashant B. Bedarkar*, Nidhi Ranpara, Vishwa Sawaliya, Mukesh B. Nariya, Pradeep Kumar Prajapati and Biswajyoti Patgiri
ABSTRACT
Introduction-Nishamalaki [combination formulation of Turmeric and Indian goose berry (Emblica officinalis Gaertn.)]; is recommended in Ayurvedic classics, proven efficacious and widely practiced in the management (treatment, prevention of complications) of Madhumeha (Diabetes Mellitus). Dose related antihyperglycemic activity of Nishamalaki prepared by levigation method has not been evaluated till the date. Aims and objectives-To evaluate dose related antihyperglycemic activity of Nisha Amalaki yoga. Materials and methods-Antihyperglycemic study of Nisha Amalaki yoga (ASBNAC) was conducted after approval of IAEC at 2 dose levels (43.29 and 260mg/kg) and Standard control (SC) Glibenclamide (0.065 mg/kg)given orally 1hr before Glucose overload, in acclimatized and overnight fasted Swiss albino mice. BSL were recorded initially and at 30, 60, 90 and 120min after Glucose overload. Results-Statistically insignificant difference in between blood sugar of test drugs, water control and standard control groups suggested cohort experimental conditions. ASBNAC at both the dose level showed comparative reversal of BSL at all test intervals after 30 minutes, whereas Glucose control group had shown statistically significant hyperglycemia. Conclusion-Nisha Amalaki yoga exhibited dose related antihyperglycemic effect at 43.29 and 260mg/kg, orally corresponding to 0.33gms and 2gms single human dose.
Keywords: Nishamalaki, Turmeric, Phyllanthus Emblica, Amalaki, Indian goose berry, Antihyperglycemic.
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