MITIGATION OF RADIATION AND MERCURY INDUCED RENAL BIOCHEMICAL CHANGES IN MICE
Aruna Chakrawarti, Sangeeta Vyas, Jayshree Banot, Manoj Kumar Bana, Manisha Agarwal and R. K. Purohit*
ABSTRACT
The environmental contamination due to heavy metal compounds such as mercuric chloride causes highly toxic effects on renal tissues of mice. It is now evident that toxic substance like mercuric chloride is a cumulative poison and is considered as a direct acting toxicant. Radiation has tremendous therapeutic benefits for humans: It is used as radiotherapy for different malignant diseases. However, it is also associated with the risk of serious adverse effects. The deleterious effects of ionizing radiation are associated with alterations in oxidizing systems. The present study has been undertaken to assess the radiation and mercury induced oxidative damage on kidney of mice and their protection by antioxidants such as Moringa (flavones), using Swiss mice as an experimental model. The animals were irradiated with 2.5 Gy of gamma radiation with or without mercuric chloride (0.5 ppm) treatment. In the experimental mice the Moringa was given seven days prior to mercuric chloride or gamma radiation treatment. The different biochemical parameters viz., total proteins, glycogen, cholesterol, acid and alkaline phosphatase activities, DNA and RNA were noticed in the form of increase or decrease. After combined treatment of radiation and mercuric chloride the more severe changes were observed showing synergistic effect. An early and fast recovery in the Moringa treated mice may be due to the protective potential of the drug.
Keywords: Radiation, Mercuric chloride, Kidney, Moringa.
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