European Journal of Biomedical and Pharmaceutical Sciences

ANALYSIS OF ESTEROGENIC ACTIVITY OF PUNICA GRANATUM SEEDS IN RATS

Saranya G., Kalpana M. B., Kaviya A. S., Praba P., Ramya K., Abinaya K., Hemalatha R., Ranjani P., Yazhini S., Sridevi P., Shobanabai H. and Sivamani P.

ABSTRACT

Female Hormonal System Estrogens are a class of steroid hormones linked principally with the control of female sex organ responsiveness and of reproduction. The important endogenous estrogens are 17 β-estradiol, estrone, and estriol. The most potent biogenic form is 17β-estradiol. Estrogens are biosynthesized in the ovary. Estrogenic compounds derived from plants are termed phytoestrogens. The major chemical groups of phyto-estrogens are classified as flavonoids, (flavones, flavanones, and isoflavanoids) coumastrans, lignans, and myoestrogens. These compounds interacting with the estrogenic receptor exert estrogenic activity, such as uterotropic effect, sterility or disruption of normal reproductive processes occurs in farm animals grazing in postures with plant sources high in phyto-estrogens. In humans cancer protective properties have been associated with phyto-estrogens (Munson et al., 1996).

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