European Journal of Biomedical and Pharmaceutical Sciences

PREDOMINANCE AND CLINICAL CHARACTERISTICS OF BURKITT LYMPHOMA IN SUDANESE PATIENTS

Wala Eldin Osman Elradi*, Abdel Rahim Mahmoud Muddathir, Badreldin Yousif, Haala Gabra Butrous, Elharam Ibrahim Abd allah and Ream Elzain Abdelgadir

ABSTRACT

Introduction: Burkitt lymphoma (BL) is a type of B lymphocyte lymphoma characterized with high proliferation rate. This study aimed to investigate age and gender distribution in addition to the predominant sites of cancer among Sudanese patients with BL. Materials and Methods: This was retrospective cross-sectional study conducted in private histopathology laboratory at Khartoum state-Sudan, during the period from June 2014 to June 2017. The data were collected from 35 confirmed BL patients’ file records at the histopathology laboratory. Archived Paraffin embedded sections were processed and prepared stained tissue slides re-interpreted by haematoxylin and Eosin in addition to the Immunohistochemistry panel for confirmation. Results: The study conducted on 35 BL patients (60% males, 40% females), with Male: Female ratio, 1.5:1, their age ranged between (2-57) years old. 54.29% of them their age were less than 5 years old and 14.29% were more than 18 years old, while 31.43% their aged ranged between 6-18 years. The collected samples showed that the Burkitt’s lymphoma found at mandibular, pelvic mass, tongue and abdominal lymph node site, usually at adult age group (above the 18 years old) and mainly found in a females group, while for children less than 18 years old, Burkitt’s lymphoma present mostly in male group at abdominal mass, abdominal lymph nodes, terminal lymph nodes and appendix. Conclusion: The study revealed that Sudanese children under 5 years old and younger people were more susceptible to the disease, commonly male patients and the most cancer site involved is the abdomen.

Keywords: BL: Burkitt’s lymphoma, clinical, age.