European Journal of Biomedical and Pharmaceutical Sciences

TO FIND OUT THE CORRELATION OF THROMBOCYTOPENIA WITH D-DIMER AN INDICATOR OF SEVERITY OF DENGUE HEMORRHAGIC FEVER

Farwa Sijjeel, Dr. Rukhshan Khurshid* and Mateen Izhar

ABSTRACT

Dengue is a mosquito-borne infectious disease, rising health problem worldwide and there is a need to find out a marker associated with severity of disease. Study was therefore designed to find out the correlation of thrombocytopenia with D-Dimer an Indicator of severity of dengue hemorrhagic fever. The study included 81 confirmed patients of dengue hemorrhagic fever, more than 18 years old who agreed to participate in study and fulfill inclusion criteria i.e. blood culture negative and IgM or NS-1 positive. The DHF patients divided in four grades according to WHO criteria. These were 55 males and 26 females. Values of platelet counts and D-Dimer were estimated. There were 53 (65.4%) cases belong to DHF-I, 20 (24.6%) cases belong to DHF-II, and 8 (9.88%) cases belong to DHF-III, and DHF-IV. 55 (67.9%) were male and 26(32.1%) were female. It is observed that 42% patients have an age of ≤ 30, 28.4% with age range 31-45 years, 29.6% with age range 46-60 years. Majority of patients (29.6%) had their platelet counts below 25000, 23.5% between 25000 and 50000. A dominant majority (72.8%) had their D dimer levels in between 201–700. Positive significant correlation (P<0.001) was observed between platelet count and D-dimer with r value 0.53. The DHF-I group had D dimer levels for all of the cases below 700. Study concluded that increased level of D-Dimer Levels along with thrombocytopenia may be an indicator of severity of dengue hemorrhagic fever.

Keywords: Dengue hemorrhagic fever, thrombocytopenia, D-dimer.