Abstract
SPECTROFLUORIMETRIC DETERMINATION OF ETILEFRINE HYDROCHLORIDE IN PURE FORM AND PHARMACEUTICAL PREPARATION

Khalid A.Mahmoud. Attia, Nasr M. El-absawy, Ebrahim Abolmagd*

ABSTRACT

A Simple, rapid, sensitive, accurate and precise spectrofluorimetric method was developed for the determination of etilefrine (ETI.) in bulk powder and in pharmaceutical preparation. This method is based on measuring the native fluorescence of ETI. in methanol at 304 nm after excitation at 276 nm using 1 ml of acetate buffer pH 4. All variables that affect fluorescence intensity such as diluting solvents, pH buffer and buffer volume were studied and optimized .The fluorescence-concentration plot was rectilinear over the range of 0.5-8 μg/ml with a lower detection limit (LOD) of 0.121 μg/ml and lower quantification limit (LOQ) of 0.367 μg/ml. The method was validated and successfully applied to the determination of ETI tablets with an average percent recovery ± RSD% of 100.05 ± 0.991. The obtained results were statistically compared with those of the reported method by applying t- test and F-test at 95% confidence level and no significant difference was observed regarding accuracy and precision.

Keywords: Etilefrine, Spectrofluorimetric, pure form, Pharmaceutical preparation.


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