European Journal of Biomedical and Pharmaceutical Sciences

IMPACT OF HYPO AND HYPERTHYROIDISM ON SERUM LEVEL OF CALCIUM, PHOSPHORUS AND MAGNESIUM IN SUDANESE PATIENTS IN KHARTOUM STATE

Ayman Makki Elgassim, Mariam Abbas Ibrahim*, Musaab Hamad Saad, Mohammed Maghazi Ahamed, Sheema Ahmed Hussein and Abdel Aziz Hamza Alhaj

ABSTRACT

Background: Thyroid hormones exert their effect on all tissue and modulate the rate of metabolic activity. The role of thyroid hormones on mineral metabolism is not well understood and the underlying mechanism too. The present study was undertaken to assess and analyze the alterations of the levels of serum calcium, phosphorous and magnesium and their relation with T3, T4 and TSH in hyper and hypothyroid patients. Materials and methods: in this case control study, 50 apparently healthy individuals and 100 patients (50 hyper and 50 hypothyroidism) were included. Serum calcium, phosphorous and magnesium levels were estimated by colorimetric method. Results: the levels of Calcium was significantly decreased in hypothyroidism Patients compared to control group (Mean±SD:8.08±0.95, p.value:0,00). and was significantly increased in hyperthyroidism patients compared to control group (Mean±SD:11.67±1.4, p.value:0,00). The levels of phosphorous was significantly increased in hypothyroidism Patients compared to control group (Mean±SD:4.61±0.5, p.value:0,00) and was significantly decreased in hyperthyroidism patients compared to control group (Mean±SD:1.94±0.6,p.value:0,00). The levels of Magnesium was significantly decreased in hypothyroidism Patients compared to control group (Mean±SD:1.74±0.5, p.value:0,00). and was significantly increased in hyperthyroidism patients compared to control group (Mean±SD:2.95±0.9,p.value:0,00). In conclusion: In hyperthyroidism Calcium and Magnesium are elevated and Phosphorous is decreased, while in hypothyroidism Calcium and Magnesium is decreased and phosphorus is increased.

Keywords: Thyroid disorders, minerals, hypothyroidism, hyperthyroidism, Sudanese.