European Journal of Biomedical and Pharmaceutical Sciences

INFLAMMATORY MARKER IN SUDANESE SICKLE CELL ANEMIA PATIENTS

Tasniem Mohamed Fawzi* and Ibrahim Khider

ABSTRACT

Background: Sickle cell disease (SCD) was recognized as inflammatory condition. C_reactive protein (CRP), white blood cell (WBC) and Erythrocyte Sedimentation rate (ESR) consider as biomarkers for inflammation. Objective: The present study aimed to assess the role of CRP, ESR and WBC count among Sudanese patients with sickle cell disease. Material and Method: This is case control study which conducted at Khartoum state during the period from May to August 2017. A total of 100 Sudanese patients with sickle cell disease (45 were in sickle cell disease and 55 were healthy individuals). Results: The result showed that TWBC level was significantly increased in SCD (24.95±14.73) when compared to control subjects (6.79±1.77) with p-value 0.000.Lymphocyte level was significantly increase in SCD (38.47±20.62) when compared in control (30.05±5.88) with p-value 0.005. Neutrophil level was significantly increased in SCD (93.97±4.79) when compared with control (45.36±3.56) with p-value 0.001. Conclusion: The study concluded that inflammatory markers were significantly higher In SCD.

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