European Journal of Biomedical and Pharmaceutical Sciences

NANOSTRUCTURED LIPID CARRIER: A NOVEL APPROACH

Yelmame Sonali D.*, S. B. Gondkar and R. B. Saudagar

ABSTRACT

The primary and foremost aim of writing this article is to focus on the importance and benefits of Nanostructured Lipid Carrier loaded drug delivery systems. The drug can be effectively distributed in the body by following various mechanism and there are also some limitations of conventional dosage forms like poor solubility, absorption, first pass metabolism and poor bioavailability, hence need for this nano structured based drug delivery systems was developed. This technique is effective to overcome the above mentioned drawbacks and also this helps us in reducing the systemic side effects, dose and dosing frequency. The most important action is the site specificity. Since there are various types of nano carriers among those SLN is effective for incorporation of hydrophilic drugs into it. But there are several disadvantages making the drug delivery less effective. The different route of administration is as like oral, topical, transdermal, ocular, rectal, vaginal, parenteral, sublingual etc. This review outlines the various parameter involved in preparation, evaluation and development of NLC’s an effective drug carrier and by giving the wide pharmaceutical and industrial application.

Keywords: Nanostructured lipid carrier, SLN, Bioavability, Conventional dosage system.