European Journal of Biomedical and Pharmaceutical Sciences

EPIDEMIOLOGY OF ADVERSE DRUG REACTION WITH SECOND LINE DRUGS AMONG PATIENTS TREATED FOR MULTI DRUG RESISTANT TUBERCULOSIS

Rajendra Prasad*, Abhijeet Singh, Nikhil Gupta, Giridhar B. Hosmane

ABSTRACT

Multi Drug Resistant Tuberculosis (MDR-TB) is considered to be a global public health problem with notoriously difficult and challenging treatment. Adverse drug reactions (ADRs) associated with Second Line Drugs (SLD’s) can have severe impact on efficient management of patients with MDR-TB. It is necessary to estimate the frequency of ADRs encountered during the treatment with SLD’s. Various studies have reported that gastrointestinal ADRs are most common followed by ototoxicity with more than half of patients requiring either regimen modification or discontinuation. MDR-TB can be cured successfully with appropriate combination of drugs if adverse events associated with them can be can be managed aggressively and timely. There is urgent demand for newer and less toxic drugs to treat MDR TB patients.

Keywords: Adverse Drug Reactions; MDR-TB; Second Line Drugs.