European Journal of Biomedical and Pharmaceutical Sciences

RAFT FORMING SYSTEM A VALUABLE EXPANSION IN GRDDS

Shaikh Siraj Nawaj*, Aamir Sohel, G. J. Khan, Mujahid Khan and Shaikh Zaker

ABSTRACT

Gastro retentive drug delivery system plays a vital role among novel drug delivery systems. The retention of oral dosage forms in the upper GIT causes prolonged contact time of drug with the GI mucosa, leading to higher bioavailability, and hence therapeutic efficacy, reduced time intervals for drug administration, potentially reduced dose size and thus improved patient compliance Gastroretentive drug delivery system is facing many challenges which can be overcome by upcoming newly emerging approach i.e. raft forming system. The present study provides valuable information & highlights advances in this raft forming system. This review focus on various factors aspects of the raft forming system, different types of smart polymers used for their formulation, mechanism, formulation and evaluation of raft forming system.

Keywords: Raft, Gastric residence time, Gastroretentive, Floating, Effervescent; applications etc.