European Journal of Biomedical and Pharmaceutical Sciences

PIRACETAM-A BOON FOR ALZHEIMER’S DISEASE

Noopur Khare*, Prakash Singh and Pragati Khare

ABSTRACT

Neuropsychiatric symptoms (NPS) like psychosis, depression and aggression are considered the main characteristics of Alzheimer’s disease (AD). Piracetam is a derivative of the neurotransmitter gamma-aminobutyric acid (GABA) which is mainly responsible for the restoration of cell membrane fluidity. Piracetam has antithrombotic, neuroprotective, rheological and anticonvulsant properties and also improves neuroplasticity. It has been reported that piracetam decreases erythrocyte adhesion to vascular endothelium, inhibit the vasospasm and stimulate microcirculation. It is useful in the treatment of vertigo, cognitive disorders, dementia, dyslexia and sickle cell anemia. It improves learning, memory, brain metabolism and capacity. Piracetam protects the cells against hypoxia. Nowadays, there is increased use of nootropic drugs for the treatment of CNS disorders.

Keywords: Piracetam, Alzheimer’s disease, neurodegeneration, memory.