Abstract
ROLE OF HESPERETIN & PYRIDOXINE PROTECT IN THE NIGROSTRIATAL DOPAMINERGIC PROJECTION IN A NEUROTOXIN MODEL OF PARKINSON’S DISEASE

Kandpal Eakta* and Bhatt Priyanka

ABSTRACT

Parkinson‘s is a neurodegenerative disease. It is characterized mainly by the movement disorders like bradikinesia, postural instability, rigidity and resting tremors and an impairment of postural balance. It is a progressive condition causing degeneration of Dopaminergic neurons in the substantia nigra resulting in the progressive loss of dopamine containing neurons which is a common signs of aging, so it is a problem which is started commonly at the age of 60. It has been suggested that oxidative stress plays a role in the etiology and progression of PD. For instance, low levels of endogenous antioxidants, increased reactive species, augmented dopamine oxidation, and high iron levels have been found in brains from PD patients. In laboratory the parkinsonism is induced by chemicals (MPTP, Mangnese, Cyanide, Reserpine, Carbon mono oxide) and neuroleptic drugs. Flavonoids (Hesperidins, Quercitin and Hesperetin) are the phenolic constituents obtained from plant origin having potential antioxidant property have been suggested to play an important role in the prevention of neurodegenerative diseases, including Parkinson's and Alzheimer's diseases. Many vitamins like A, B, C, E have also shown protective effects against oxidative-induced neuronal death. In this paper, we have reviewed about the mechanisms by which Hesperetin and Vitamin B6 antioxidants can produce protection in PD.

Keywords: PD, Flavonoids, Substantia nigra, Antioxidant.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: APRIL ISSUE PUBLISHED

    APRIL 2024 Issue has been successfully launched on 1 APRIL 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT