European Journal of Biomedical and Pharmaceutical Sciences

ROLE OF HESPERETIN & PYRIDOXINE PROTECT IN THE NIGROSTRIATAL DOPAMINERGIC PROJECTION IN A NEUROTOXIN MODEL OF PARKINSON’S DISEASE

Kandpal Eakta* and Bhatt Priyanka

ABSTRACT

Parkinson‘s is a neurodegenerative disease. It is characterized mainly by the movement disorders like bradikinesia, postural instability, rigidity and resting tremors and an impairment of postural balance. It is a progressive condition causing degeneration of Dopaminergic neurons in the substantia nigra resulting in the progressive loss of dopamine containing neurons which is a common signs of aging, so it is a problem which is started commonly at the age of 60. It has been suggested that oxidative stress plays a role in the etiology and progression of PD. For instance, low levels of endogenous antioxidants, increased reactive species, augmented dopamine oxidation, and high iron levels have been found in brains from PD patients. In laboratory the parkinsonism is induced by chemicals (MPTP, Mangnese, Cyanide, Reserpine, Carbon mono oxide) and neuroleptic drugs. Flavonoids (Hesperidins, Quercitin and Hesperetin) are the phenolic constituents obtained from plant origin having potential antioxidant property have been suggested to play an important role in the prevention of neurodegenerative diseases, including Parkinson's and Alzheimer's diseases. Many vitamins like A, B, C, E have also shown protective effects against oxidative-induced neuronal death. In this paper, we have reviewed about the mechanisms by which Hesperetin and Vitamin B6 antioxidants can produce protection in PD.

Keywords: PD, Flavonoids, Substantia nigra, Antioxidant.