EVALUATION OF POTENTIAL APHRODISIAC ACTIVITY OF HENHANCE- A POLYHERBAL FORMULATION IN MALE ALBINO RATS
Ruchismita Ghosh, Biplav Syngkli, I. Aparna Lakshmi, Dr. Shivalinge Gowda K. P.*, Nataraj Loganayaki, Khader Shareef K. S. and Venkateswarlu K.
ABSTRACT
Aim: The present study was aimed to evaluate aphrodisiac activity of HENhance-a polyherbal formulation developed by Suguna Foods Pvt Ltd in male albino rats. Materials & Methods: The acute toxicity of HENhance was evaluated by standard OECD guidelines up to a dose of 2000mg/kg b.w p.o. Eighteen male albino Sprague Dawley rats (180-200mg) were divided in to three groups. Group I- served as a vehicle treated control, group II- received 200mg/kg,b.w, p.o HENhance poly herbal formulation and group III- received standard drug sildenafil citrate 5mg/kg.b.w, p.o. for a period of 21 days. The female rats involved in mating were made receptive by hormonal treatment. The male treated groups of rats were observed for mounting behavior, mating behavior, orientation activity and for libido. At the end of experimental period the serum testosterone levels were observed. Results: The effective dose of HENhance was found to be 200mg/kg b.w from the acute toxicity studies. Oral administration of HENhance at a dose of 200mg/kg b.w significantly increased the serum testosterone, mounting behavior, orientation towards female rats, genital grooming, mounting frequency, intromission frequency and ejaculation latency along with decrease in mounting latency and intromission latency. Conclusion: This study suggests that HENhance was effective for sexual performance and safe alternative remedy for sexual disorders.
Keywords: Aphrodisiac, Testosterone, Libido.
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