EFFECT OF REPAGLINIDE AND CURCUMIN COMBINATION ON OXIDATIVE STRESS AND BIOCHEMICAL PARAMETERS IN STZ INDUCED DIABETIC RATS
Jyothi P., Babu Rao B. And Dr. Narsimha Reddy Y.*
ABSTRACT
Aim: Repaglinide is an antihyperglycemic agent used for the treatment of diabetes mellitus. It has a good safety and efficacy profile in diabetic patients with complications in renal impairment. Curcumin is a diaryl heptanoid and is the principal curcuminoid of the turmeric. Both repaglinide and curcumin have antioxidant properties. The main aim of the present study was to examine the protective effect of repaglinide in the presence of curcumin in streptozotocin (STZ) induced diabetic rats. Methods and Results: For this study all the rats were divided into four groups (n=6). Diabetes was induced into all the rats by STZ 55 mg/kg, intra peritoneally. Group I represents diabetic rats as control and received normal saline orally, group II rats administered repaglinide orally for 28 days, group III rats administered curcumin orally for 28 days and group IV rats administered with curcumin and followed by repaglinide for 28 days orally. Blood samples were collected on 1st day, 7th day, 14th day, 21st day and 28th day and used for further analysis. STZ administration destroys the β-cells and glucose in the blood of diabetic rats was increased and there by increases the SGOT, SGPT, total cholesterol, reactive oxygen species (ROS) and lipid peroxidation and decreases the total proteins, and serum insulin levels. By administration of repaglinide, curcumin and repaglinide+curcumin combination reverses the results significantly. Conclusion: Combination of curcumin with repaglinide showed significant changes in various serum biochemical parameters and antioxidant status than repaglinide and curcumin alone groups.
Keywords: Antioxidant, Biochemical parameters, Curcumin, Lipid peroxidation.
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