Abstract
FIVE SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF AMISULPRIDE IN PURE FORM AND PHARMACEUTICAL DOSAGE FORM

Khalid A.M. Attia, Mohammed W.I. Nassar and Ahmed M. Abd El Zaher*

ABSTRACT

Five Simple, rapid, sensitive, accurate and precise stability-indicating spectrophotometric methods were developed for the determination of Amisulpride in bulk powder and in pharmaceutical preparation. Method (A) First derivative method(1D), Method (B) Ratio derivative method(1DD), Method (C) Ratio difference method, Method (D) Mean centering method, Method (E) Dual wavelength method are used for the determination of intact Amisulpride in presence of its degradation product. The methods were validated and successfully applied to the determination of Amipride ® 50mg tablets with an average percent recovery ± RSD% of 100.26± 1.097 for method (A), 98.177 ± 1.130 for method (B), 99.60 ± 1.371 for method (C), 101.9 ± 1.349 for method (D) and 98.85 ± 1.007 for method (E). The obtained results were statistically compared with those of the reported method by applying t-test and F-test at 95% confidence level and no significant difference was observed regarding accuracy and precision.

Keywords: Amisulpride, First derivative, Ratio derivative, Ratio difference, Mean centering, Dual wavelength.


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