European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS AND CHARACTERIZATION OF AZO COMPOUNDS AS PRODRUGS OF SULFONAMIDES CONTAINING THYMOL MOIETY AND ITS IN-VITRO DEGRADATION STUDY

Shivaji Madhukarrao Koshti*, Harshal Madhukar Bhamare and Dhananjay Hiraman More

ABSTRACT

The aim of this study was to investigate the drug release study of antibacterial compounds such as thymol and sulfonamides. The drug release study of these substances were done by inoculation of them against bacterial strains which were synthesize azoreductase enzyme similar to enzyme secreted by colon microflora. The newly synthesized azo compounds which were used for drug release study, were inoculated with pseudomonas aeruginosa bacteria which secrete the azo reductase enzyme causing a release of the parent compound. Thymol and sulphonamides were the most effective compounds against the bacteria included in this study, with a low toxicity to human colon. The use of thymol and sulphonamides combination as azo compounds gives the new tool for colon targeting treatments as well as for urinary tract infections, and they can also find variety of applications in the field of medicinal and pharmaceutical chemistry.

Keywords: Sulfacetamide, Sulfathiazole, thymol, azo compounds, Bacterial degradation, Azoreductase enzyme.