European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF ANTI-MICROBIAL POTENTIAL OF POLYHERBAL SIDDHA FORMULATION AGHIL KATTAI CHOORANAM (AKC) AGAINST GARDNERELLA VAGINALIS AND CANDIDA ALBICANS

X. Helen Sathiya*, N. Anbu, P. Parthibhan, K. Kanakavalli

ABSTRACT

Bacterial vaginosis (BV) is a common vaginal infection associated with numerous gynecological and obstetric complications. This condition is characterized by the presence of thick adherent vaginal biofilms, composed mainly of Gardnerella vaginalis. This organism is thought to be the primary etiological cause of the infection. Vaginal candidiasis (VC) is another most common gynecological problem seen in primary care. Candida albicans account for 90% of the infection. Antibiotic therapy for the clinical management of BV and VC often ends with failure due to due to resistance offered by the pathogen towards such drugs. Hence there is a need of developing antimicrobial lead from alternate origin which is tend to act my multiple mechanism .In recent years, there has been a growing interest in the field of drug discovery for developing new antimicrobial agents from herbal origin to combat microbial resistance. Siddha system of medicine have identified numerous medicinal plants and its applications in strengthening human health care system and the formulations based on such medicinal plants play an important role in alleviating most pathogenic infection occurs in humans. One such formulation is Aghil kattai Chooranam (AKC) used in the traditional practice for clinical management of several infectious diseases. The main objective of the present investigation is to evaluate the anti-microbial potential of AKC against vaginal pathogens Gardenerella vaginalis and Candida albicans by agar disc diffusion method. The result of the study signifies that siddha formulation AKC offers significant activity against Gardenerella vaginalis with zone of inhibition varying from 7mm to 12 mm when compare to standard Metronidazole with maximum zone of 25 mm at a same time the formulation AKC is not effective against Candida albicans. In conclusion the Siddha formulation AKC may use for the clinical management of bacterial vaginosis and leucorrhoea associated with Gardenerella vaginalis infection.

Keywords: Bacterial vaginosis, Vaginal candidiasis, Aghil kattai Chooranam , Antimicrobial, Gardenerella vaginalis , Candida albicans.