European Journal of Biomedical and Pharmaceutical Sciences

DESIGN AND INVITRO CHARACTERIZATION OF BUSPIRONE TABLETS FOR BUCCAL DRUG DELIVERY SYSTEMS

Kondru Lalitha*, Palepu Swathi, I. Sharmila, G. Annapurna, S. Siva Ganesh and B. Jyothi

ABSTRACT

In the current study Regulated drug release in first order manner attained indicates that the hydrophilic matrix tablets of Buspirone was prepared using Carbopol 934 and HPMC K100 can successfully be employed as a buccoadhesive controlled released during delivery system. The precompression blend foe all formulations were subjected to various evaluation parameters and the results were found to be within limits. The post compression parameters for all the formulations also found to be within limits. Slow, controlled and complete release of Buspirone over a period of 9 hours was obtained from matrix tablets formulated employing HPMC K 100 (F5 Formualtion) with 98.67% drug release.

Keywords: Buspirone, buccoadhesive.