FORMULATION AND EVALUATION OF ORALLY FAST DISSOLVING WAFER OF ETODOLAC USING NATURAL GUM
Darekar A. B., Sonawane S. M.* and Saudagar R. B.
ABSTRACT
Oral Wafers are intended for the application in the oral cavity on the tongue, drug absorbs totally through tongue artery and entered in to systemic circulation. So, they are an innovative and promising dosage form especially for use in pediatrics and geriatrics. Etodolac was selected as the active drug as it has low solubility and it is indicated in to Anti-arthritis where an immediate relief is always needed. The prepared wafers, based on different formulations, were evaluated. A 32 full factorial design was used to optimize the film. Natural Gum was found to be a good film forming agent. The concentration of PVP and Grevillea Robusta Gum were selected as independent while % drug release was a dependable variable in the formulation. Formulation F9 was found to be the optimized among all nine batches with 98.26% release. Increased in the levels of PVP K30 causes the decreased in the folding endurance and increased in the % elongation. Surface pH of all the formulation was measured and found in acceptable pH range. DSC spectra of film shown the drug was totally embedded within polymer matrix, so stability of drug was also increased in formulation. Stability study showed that formulation was stable over a period of stability conditions without any unacceptable changes.
Keywords: Etodolac, Solvent Casting, Oral Wafer, Grevillea Robusta Gum, PVP K30.
[Full Text Article]
Impact Factor : 6.044
