European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF SINTERED MATRIX TABLET OF VENLAFAXINE HYDROCHLORIDE

Smita S. Aher*, Amol R. Bodke and R. B. Saudagar

ABSTRACT

Venlafaxine HCl has short half-life 4-5hrs, therefore it need to be frequently administered during therapy which gives patient incompliance A Sintered matrix Tablet reduce Dosing Frequency and Improve the patient Compliance. Therefore, in this Study attempt has been done to design and evaluate the effect of processing method, sintering condition and subsequent drug release of Venlafaxine HCl Sintered Matrix Tablet. Were Prepared using combination of Eudragit RL100(10-50%w/w)by direct compression Method .The Prepared Tablet were using 750 c temperatures Thermal Treatment(Hot air Oven) for time period The Sintered Tablet Chartered by Hardness friability and in vitro dissolution tests. It was evident that different Processing method, time sintering for identical formulation significantly impact the release profile of drug. From prepared matrices, it was noticed that the Venlafaxine HCl release rate was inversely related to time of Sintering.

Keywords: Venlafaxine HCl Unsintered matrix tablet, in vitro drug Release, diffusion, Sustained release sintered matrix tablet.