European Journal of Biomedical and Pharmaceutical Sciences

IN VIVO SCREENING OF ANALGESIC AND ANTIULCER ACTIVITY ON CARUM CARVI SEEDS

V. Swathi*, V. Sathish Kumar, Dr. Sk. Abdul Rahaman and Dr. Anjana Male

ABSTRACT

The present study was designed to investigate the antiulcer and analgesic potential of carum carvi seeds. caraway seeds use is common in diet, so there is no need for special administration of the drug and by little increase in intake quantity, the use of analgesics is abolished. Antiulcer activity was also evaluated by aspirin induced ulcer models. Effect of concurrent administration of ethanolic and aqueous extracts of seeds extract Carum carvi at a dose of 100 and 200 mg/kg b.w. respectively was given by oral route. Ethanolic and aqueous extracts of Carum carvi seeds significantly reduction in gastric content, total acidity, ulcer index, and increase in pH of gastric pylorus ligation ulcer model. In comparison with the standard drug, the results of hydro alcoholic extract at 100 mg dose showed good analgesic & at 200 mg dose showed antiulcer activity compared with a standard drug. Extracts of Carum carvi may be useful as a natural analgesic in the treatment of ulcer, inflammation, and pain.

Keywords: Carum carvi, antiulcer activity, aspirin, and analgesic.