European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION DEVELOPMENT AND EVALUATION OF BETAMETHASONE SODIUM PHOSPHATE IN-SITU OPHTHALMIC GEL

Dr. R. B. Saudagar* and Rasika D. Ghodke

ABSTRACT

Betamethasone sodium phosphate is adrenocortical steroid which is used in the treatment of ophthalmic ailments like infections, inflammations, conjunctivitis, to prevent post- operative inflammation after cataract surgery etc. Commercially, Betnesol (0.1%) eye drop solution is available and it is quite easy for the administration. However, the product has drawback of poor bioavailability due to several factors such as tear production, non-productive absorption, transient residence time, and impermeability of corneal epithelium. In order to improve the bioavailability, residence time and longer duration of action, an attempt was made to formulate in-situ ophthalmic gel of Betamethasone sodium phosphate. In present study Poloxamer 407 and HPMC E50 were used as polymers. Poloxamer 407 was used as a Temperature sensitive polymer and HPMC E50 was used as mucoadhesive polymer. All 9 prepared formulations were optimized by 32 factorial design. The prepared formulations were evaluated for pH, clarity, viscosity, drug content, gel strength, bioadhesive strength, In Vitro drug release, isotonicity test, HET-CAM test and stability studies.

Keywords: Betamethasone sodium phosphate, Poloxamer 407, HPMC E50, In-Vitro drug release, HET-CAM test.