Abstract
EVALUATION OF CYTOTOXIC ACTIVITY OF ZANTHOXYLUM ACANTHOPODIUM IN DALTON’S LYMPHOMA ASCITES CELLS INDUCED CANCER IN MICE

Joyeeta Bhattacharya*, Aparna Lakshmi I., Sudipta Ata, Oly Sen Sarma

ABSTRACT

Objective: The quest for plants with valuable medicinal properties continues to receive keen attention by many scientists for biological activities, which range from antibiotics to antitumor agents. The present study demonstrates dose dependent anti-cancer effect of Zanthoxylum acanthopodium L. fruit extracts by in-vivo methods scientifically with an objective to overcome cancer. Methods: The anti-cancer activity of the aqueous extract of Zanthoxylum acanthopodium (AEZA) and methanolic extract of Zanthoxylum acanthopodium (MEZA) were tested against Dalton’s Lymphoma Ascites (DLA) cell lines induced cancer in Swiss albino mice. The degree of protection was determined by change in body weight (gm), Percentage decrease in body weight (%), Tumour volume (ml), Packed cell volume (ml), Percentage cell viability (%), Haematological parameters (R.B.C, W.B.C and Hemoglobin content), Mean survival time (MST), % increase in lifespan (% ILS) and histopathological parameters. Results: AEZA and MEZA (200 mg/kg and 400mg/kg per oral (p.o)) have shown significant prolongation of lifespan, reduction in tumor volume, packed cell volume, cell viability, and improvement in the hematological parameters, changes in histopathological observation when compared to the rest of the groups. AEZA and MEZA at 400mg/kg b.w p.o. possess better anticancer activity than rest of its doses of other drug. The results of the present study are encouraging, as both the extracts have shown significant anticancer activity. Conclusion: The results indicate that the AEZA and MEZA (200 mg/kg and 400mg/kg b.w, p.o possess significant antitumor activity and its potency to be developed as an anticancer agent.

Keywords: Anti-Cancer; Zanthoxylum acanthopodium, Dalton’s Lymphoma Ascites (DLA), Mean survival time (MST).


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: JUNE ISSUE PUBLISHED

    JUNE 2024 Issue has been successfully launched on 1 JUNE 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT