European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF ANTI-INFLAMMATORY, ANTI-ALLERGIC AND IMMUNE MODULATORY POTENTIAL OF SIDDHA FORMULATION OMA LEGIUM BY COMPUTATIONAL DOCKING ANALYSIS

M. Sumathi*, C. Shanmugapriya and R. Meenakumari

ABSTRACT

Scabies commonly called as sirangu in tamil is a contagious skin infestation that affects an estimated 300 million people around the world every year. Current medications commonly prescribed for scabies like permethrin offers increased adverse effect. Hence it a need of the hour to explore the alternate treatment strategy from Indian traditional medicine like siddha which has several formulations comprises of herbal lead in clinical management of this chronic inflammatory condition. It is evident that the prostaglandin and histamine plays a major role in arising the symptoms of scabies such as pain, inflammation, swelling, itching etc. The main aim of the present investigation is to screen the anti-allergic and anti-inflammatory potential of phytocomponents such as Beta Pinene, Thymol and Carvacrol present in the formulation Oma legium (OL) against target histamine, cyclooxygenase and prostaglandin synthases receptors along with their respective standards using computational docking analysis. The results of the study indicates that the lead Beta Pinene, Thymol and Carvacrol possess significant inhibitory action against Histamine, Prostaglandin Synthase and cyclooxygenase II, whereas the compounds Thymol has no activity against cyclooxygenase I. Based on the results of the In-silico screening analysis it was concluded that the compound’s such as Beta Pinene, Thymol and Carvacrol present in the siddha formulation OL possess significant inhibition of inflammatory mediators therefore this formulation may have promising immuno modulatory activity and may effective against inflammatory condition like scabies.

Keywords: Scabies, Siddha, Oma legium, Histamine, Cyclooxygenase, Prostaglandin synthases, Immuno modulatory activity.